SUMMARY

Research and teaching in medicinal chemistry with over 10 years of experience. Technical expertise includes design, planning, and execution of synthetic and analytical methods of new drugs and medicinal agents. Hands on experience in chemical synthesis, enzyme isolation, purification and kinetic studies. Demonstrated ability to bring research and development projects to a successful completion, while meeting time requirements and technical specifications. Recognized for creativity, productivity, team building, leadership and commitment to the success of projects.

Operating different instruments including LC-MS, UV, NMR, HPLC, FPLC, Gel electrophoresis etc.

Teaching and supervising research students for their graduations in different branches of medicinal chemistry including organic synthesis, name reactions, reaction mechanisms, peptide synthesis, organic spectroscopy and structure elucidations.

Organic and peptide synthesis; liquid and solid phase

Writing successful grant proposals

Enzyme isolation, purification and characterization, enzyme kinetic and biochemical studies

Isolation, purification and characterization of compounds from plant sources

Data analyses. ENZFIT, GRAFIT etc for enzyme kinetics; interpreting and analyzing UV, IR NMR and mass data of organic chemicals and peptides.

Internet Browsing Extensive experience in PC, using different software, different types of chemical and biological database

 

 

PROFESSIONAL EXPERIENCE

Southwestern Oklahoma State University College of Pharmacy, Weatherford, OK

Jan 2007 -

Assistant Professor of Medicinal Chemistry

Overall responsibilities include, teaching 5-credit hours of medicinal chemistry courses for the Pharm.D. students, undertaking dispensing laboratory classes and conducting research in medicinal chemistry of my expertise and interest.

Florida A & M University College of Pharmacy, Tallahassee, FL

Sep 2004 – Dec 2006

Research Associate/Adjunct Faculty, Medicinal Chemistry

Overall responsibilities include:

  • Synthesis of various Anti-inflammatory Steroidal antedrugs derivatives (development of new synthetic route and parallel synthesis by Firstmate® parallel synthesizer).
  • Supervision of Graduate student.
  • Writing grants.
  • Teaching Physiological Chemistry to undergraduate Pharm.D. students of the College of Pharmacy.

University of Mississippi School of Pharmacy, Oxford, MS, USA

June 2002-Sep 2004

Postdoctoral Research Associate (Supervisor: Prof. R.F.Borne)

Served as a postdoctoral research associate in the Department of Medicinal Chemistry for synthetic process development (SPD) by planning and executing the projects. Involved in synthetic and analytical projects to forecast the problems and fix them during the process.

  • Synthesis of various isoquinuclidine derivatives as anti-addictive (Ibogaine analogues) Nicotinic analogues and anti-malarial agents (quinine, mefloquine and chloroquine analogues) (development of new synthetic route and parallel synthesis by QUEST automated parallel synthesizer).
  • Synthesis of cyclen analogues as novel antimalarial agents.
  • Stereoselective synthesis of 8-aminoquinoline derivatives as prclinical candidate drugs
  • Experienced in use of analytical instruments like NMR, IR, HPLC, LC-MS and interpretation of spectral data for the identification of structures.
  • Good understanding of cGMP and GLP protocols to increase the laboratory quality and production.

University of Dhaka Department of Pharmacy, Dhaka, Bangladesh,

July 1999 – August, 2004

Assistant Professor

Conducted teaching in medicinal chemistry in Department of Pharmacy. Oversaw project proposals, research planning and execution with the help of undergraduate and master students. Supervised undergraduate and graduate students.

  • Teaching in different undergraduate and master’s classes (Area: Organic Chemistry, Organic Spectroscopy and structure elucidation, Medicinal Chemistry, Pharmacognosy, biochemistry, combinatorial chemistry, drug action and design and QSAR and pharmacology).
  • Preparing, tutoring and marking different theoretical and practical classes.
  • Doing own research and also supervising undergraduate and M.Pharm students of the Department.
  • Selected and supervised undergraduate and graduate students to complete research work and writing thesis for their degrees.

Hiroshima University School of Pharmacy, Japan

October 2001 – March 2002

JSPS Postdoc. Fellow (Supervisor: Prof. E. Kimura)

Six months postdoctoral research in the Department of Medicinal Chemistry, on macrocyclic polyamines. Synthesis of quinoline and phenothiazine pendant cyclens and their Zn complexes, chemical characterization and determination of pK values by UV, Fluorescent and potentiometric pH titration have been performed. The complexes of cyclens had been shown to have anticancer and ant-HIV potentials.

University of Manchester School of Pharmacy, UK

May 2001 – August 2001

Visiting Scientist

  • Worked under the International Research Development Award Scheme of the Wellcome Trust.

University of Manchester School of Pharmacy, UK

October 1995 – March 1999

Research Fellow for Ph.D. Thesis


Carried out a research for about three and half years (October 1995 – March 1999) and submitted a dissertation to the University of Manchester, UK for the degree of PhD. The thesis primarily focussed on novel ligand design for the target enzyme trypanothione reductase, for the chemotherapy of leishmaniasis and trypanosomiasis. The following projects had been handled related to this:

  • The over expression, isolation, purification and characterization of TR from its cloned gene in E.coli plasmid
  • Enzyme assays using TR and GR with their natural and synthetic assay substrates, enzyme kinetic study with the competitive inhibitors of the enzyme for their I50 and Ki determinations using UV-visible techniques and Grafit as the enzyme kinetic software, detail study of the futile superoxide producing substrate activity of vanadate with TR, and platinum compounds’ interaction with enzyme’s -SH group was also performed. Biochemical assays involving superoxide dismutase, catalase, cytochrome c and other superoxide scavengers are also been performed.
  • Design and synthesis of a large number of TR inhibitors to involve in the inhibition studies. The inhibitors synthesized included I) Quternary alkylammonium chlorpromazines, ii) Quaternery alkylammonium clomipramines, iii) quaternary alkylammonium diphenylsulfides, iv) Nicotinium/dihydronicotinyl analogues of the quaternery ammonium compounds as redox switched prodrug leads.
  • Synthesis of trypanothione (the natural substrate of TR) on solid phase and Z-cys-gly-dimethylaminopropylamine (assay substrate of TR) and used in the TR assays .
  • Also supervised two project students in the Department of Pharmacy, University of Manchester, UK. The projects focussed on design, synthesis and study of inhibitory activity of trypanothione reductase

University of Dhaka, Department of Pharmacy,

October 1993 – July, 1999

Lecturer
  • Teaching in different undergraduate and master’s classes in the area of Pharmacognosy, spectroscopic analysis of organic compounds, organic name reactions and reaction mechanisms etc.
  • Preparing, tutoring and grading different theoretical and practical classes.
  • Also supervised project students in the Department of Pharmacy, University of Manchester, UK.

The University of Science and Technology, Chittagong (USTC)

Sep 1999 – May 2001


Part time teacher in Department of Pharmacy to teach in the area of biomolecular pharmacy

 

STRENGTHS

 

  • Pharmacy graduate with the knowledge of pharmaceutical and pharmacological matters of drugs and got in-plant training (3 months) in a big Pharmaceutical Industry in Bangladesh (EDCL).
  • Completed Foreign Pharmacy Graduates’ Equivalence Examination (FPGEE). Florida State Department of Health has already provided me the Pharmacist Intern Certificate, once complete the 2080 hours of internship will be eligible for Registered Pharmacist in the USA after passing the Licensure Examination.
  • Experienced in spectroscopic and chromatographic analysis of samples using NMR, HPLC, and LC and GC-MS.
  • Hands on experience in synthesis and characterization by spectroscopic techniques of organic molecules.
  • Can successfully work in a team environment and in a supervisory capacity
  • Good computer application skills in client-server and stand-alone environment of Microsoft products and software for analytical purpose, example: Waters Millennium 32.
  • Good communication and writing skills and capable to interact with other collaboration labs.

 

INSTRUMENTATIONS AND SOFTWARE

HPLC: Analytical and Preparative, LC & GC -MS, NMR, FTIR, UV, FPLC, and Scintillation counter
Data Management Software: Microsoft Office, Waters Empower and Millennium 32, Grafit, Chemdraw, Refman.

 

EDUCATION

 

  • Ph.D. (Med. Chem.): University of Manchester, UK (1999).
    Area of specialization: Medicinal Chemistry and rational drug design, organic and peptide synthesis, enzymology.
    Dissertation: Antiparasitic Drug Design Based on Trypanothione Reductase as a Target in the University of Manchester, UK.
  • M. Pharm. (Course: Pharmacy, and research: Phytochemistry)): Dhaka University, Dhaka, Bangladesh (1991) (First class 2nd position).
    Dissertation: Antifertility principles from Marsdenia tinctoria in the University of Dhaka
  • B.Pharm. (Hons.) Dhaka University, Dhaka, Bangladesh (1989) (First Class 1st position).

 

HONORS, FELLOWSHIPS AND AWARDS

 

  • Nominated for inclusion in the 2006-2007 edition of International WHO'S WHO of Professionals.
  • My Biography is included in 2006-2007 (6th) Edition of Who's Who in Medicine and Healthcare®.
  • International Research Development Award by “The Wellcome Trust”, UK. The Trust sponsored for performing research on “Development of Antitrypanosomal and Antileishmanial Drug leads”.
  • JSPS Postdoctoral Fellowship award (2001-2002) .
  • National Science and Technology Fellowship 1999-2001 for research excellence, awarded by the Ministry of Science & Technology, Bangladesh
  • EUFEPS ‘98 Award for Best Poster. Fourth European Congress of Pharmaceutical Sciences, Milan, September 13, 1998
  • Awarded highly competitive Commonwealth Scholarship tenable in the UK for PhD in Medicinal Chemistry, October 01, 1995 to December 31, 1998
  • Book award by Dhaka University Registrar for achieving highest marks in Honors final examination
  • Received Dhaka University Scholarship for results in the Honors and masters, examinations.

 

PUBLICATIONS

A. Book Chapter

 

M.O.F. Khan, M.S. Levi, C.R. Clark, S.Y. Ablordeppey, S.-J. Law, N.H. Wilson and R.F. Borne, Isoquinuclidines: A Review of Chemical and Pharmacological Properties. In Book Series: Studies in Natural Product Chemistry,v 34, 2007 (in press).

B. Ph.D. Thesis

Antiparasitic drug design based on trypanothione reductase as a target – a dissertation submitted to the University of Manchester for the degree of Doctor of Philosophy, January 1999.

C. M.Pharm Thesis

Antifertility principles from Marsdenia tinctoria - a dissertation submitted to the University of Dhaka for the partial fulfillment of the degree of Master of Pharmacy, December 1992.

D. Encyclopedia of Bangladesh

The encyclopedia of Bangladesh has been published by the Asiatic Society of Bangladesh in 2002 in both English and Bengali languages. I have authored the topics on 1) Anti-diarrhoeal drugs, 2) Anti-anthelmintic drugs, 3) Anti-dysenteric drugs and 4) Pharmacy Education Research in Bangladesh.

 

E. Selected Publications

 

  1. M. Omar F. Khan*, Henry J. Lee. Synthesis and pharmacology of anti-inflammatory steroidal antedrugs. Chem. Rev. 2007 (submitted, review)
  2. M.O.F. Khan*, K.K. Park, S.N. Glynn and H.J. Lee. New Steroidal Anti-Inflammatory Antedrugs: 21-Thioalkylether Derivatives of Methyl 16-Prednisolone Carboxylates. Med Chem 2007 (Accepted)
  3. M.O.F. Khan. Trypanothione reductase as a potential target for antitrypanosomal and antileishmanial drug design. Drug Target Insights, 1: 129-146, 2007.
  4. M.A. Musa, M.O.F. Khan and J.S. Cooperwood. Medicinal Chemistry and Emerging Strategies Applied to the Development of Selective Estrogen Receptor Modulations (SERMs). Current Med. Chem. 14(11), 1249-1261 (2007).
  5. M.O.F. Khan, M.S. Levi, B.L. Tekwani, N.H. Wilson and R.F. Borne. Synthesis of Isoquinuclidine analogs of chloroquine: antimalarial and antileishmanial activity. Bioorg. Med Chem, 15(11), 3919-3925 2007.
  6. M.O.F. Khan*, H.J. Lee, A simple and convenient synthesis of 21-thioalkylether derivatives of methyl 16-prednisolone carboxylates. Synthetic Communications 37: 409–415, 2007.
  7. K.-K. Park, D.–H. Ko, Z. You, M.O.F. Khan, H.J. Lee. In vitro anti-inflammatory activities of new steroidal antedrugs: [16,17-d] isoxazoline and [16,17-d]-3’-hydroxyiminoformayl isoxazoline derivatives of prednisolone and 9-prednisolone. Steroids 71: 183-188, 2006.

8.      S. Parveen, M.O.F. Khan, S.E. Austin, S.L. Croft, V. Yardley, P. Rock and K.T. Douglas*, Anti-trypanosomal, Anti-leishmanial and Anti-malarial Activities of Quaternary Arylalkylammonium 2-Amino-4-Chlorophenyl Phenyl Sulfides, a New Class of Trypanothione Reductase Inhibitor, and of N-Acyl Derivatives of 2-Amino-4-Chlorophenyl Phenyl Sulfide. J. Med. Chem. 48(25) pp 8087 – 8097,2005)

  1. M.O.F. Khan, S. Parveen, G. Seddon, and K.T. Douglas. Vanadate as a Futile, Superoxide Ion-Producing Substrate of Trypanothione Reductase from Trypanosoma cruzi. Chem. Lett. 34, 1558-9, 2005.
  2. M.O.F.Khan*, K.K.Park, H.J.Lee. Antedrugs: An Approach to Safer Drugs. Curr. Med. Chem., 12(19), 2227-2239, 2005. (Review)
  3. M.S. Levi, M.O.F. Khan and *R.F. Borne, Solution-Phase Parallel Synthesis of N,6-Disubstituted Isoquinuclidines as Ibogaine Analogs. Lett. Drug Des. Disc. 2(1), 51-54, 2005.
  4. M.S.Levi, M.O.F. Khan and R.F.Borne, Solution Phase parallel synthesis of N-substituted Isoquinuclidines. Lett. Drug Des. Disc. 1(4), 384-6, 2004.
  5. R. Chowdhury, M.U. Rashid, O.F. Khan and C.M. Hasan. Bioactivity of extractives from Stachytarpheta urticaefolia. Pharmaceutical Biology, 42, 262-267, 2004.

14.  R. Chowdhury, M.U. Rashid, O.F. Khan and C.M. Hasan. Ipolamiide and a-Spinasterol from Stachytarpheta urticaefolia. Biochemical Systematics and Ecology 31, 1209-1211, 2003.

15.  M.O.F. Khan, S.E. Austin, C. Chan, H. Yin, D. Marks, S.N. Vaghjiani, H. Kendrick, V. Yardley, S.L. Croft and K.T. Douglas. Use of an Additional Hydrophobic Binding Site, the Z Site, in the Rational Drug Design of a New Class of Stronger Trypanothione Reductase Inhibitor, Quaternary Alkylammonium Phenothiazines. J. Med. Chem 43(16) 3148-56, 2000.

  1. S.E. Austin, M.O.F. Khan and K.T. Douglas. Rational Drug Design Using Trypanothione Reductase as a Target for Antitrypanosomal and Anti-leishmanial Drug leads. Drug Design and Discovery. 16 5-23, 1999.
  2. Chowdhury A.K.A., Khan M.O.F., Hashim M.F. Antifertility principles from Marsdenia tinctoria: Pharmacological and phytochemical studies. Pure and Applied Chemistry, 66(10/11), 2343-2346, 1994.

 

F. Other Publications

  1. MT Rahman, OF Khan, S Saha, M Alimuzzaman. Antidiarrhoeal activity of bark extract of Careya arborea Roxb. Fitoterapia 74, 116-118, 2003.
  2. MT Rahman, N Begum, M Alimuzzaman, MOF Khan, Analgesic activity of Enhydra fluctuans, Fitoterapia 73(7-8), 707-9, 2002.
  3. M.Ahmed, Islam, MM, Hossain CF, Khan MOF, A preliminary study on the analgesic activity of Gangea Maderaspatana. Fitoterapia 72(5):553-4, 2001.
  4. A. K. Azad Chowdhury, M. S. Ali, M O F Khan and F Rahman, Bioactivity screening of extracts and isolated compounds of Ipomoea fistulosa, Bang. J. Sci. Res., 1998; 16(1): 101-103.
  5. A.K.A. Chowdhury, M.S. Ali, M.O.F. Khan, Antimicrobial Activity of Ipomoea Fistulosa extractives. Fitoterapia LXVIII(4), 379-380, (1997).
  6. A.K.A. Chowdhury, M.A. Mannan, M.O.F. Khan and F. Rahman. Brine shrimp lathality study with Pergularia daemia. Bang. J. Physiol. Pharmacol. 13(1) 2-3, 1997.
  7. A.K.A. Chowdhury, M.A. Mannan, M.O.F. Khan and F. Rahman. In vitro antimicrobial activity of Pergularia daemia. Bang. J. Li. Sci 8(2) 71-72, 1996.
  8. D.K.Chowdhury, C.K.Paul, R.Banoo, B.K.Datta, and M.O.Faruk Khan, Bioavailability studies of aspirin tablets by urinary excretion method, Bangladesh J. of Physiology and Pharmacology, 10(2), 53-54, 1995.
  9. Reza M.S., Faruk Khan M.O., Rashid M.A., Azad Chowdhury A.K. In vitro antimicrobial activity of Ipomoea fistulosa, Fitoterapia, LXV (5) 465-66, 1994.
  10. Azad Chowdhury A.K., Faruk Khan M.O., Hashim M.F., Rashid M.A. New steroidal compounds from Marsdenia tinctoria. Journal of Bangladesh Academy of Sciences, 18(1), 39-45, 1994.
  11. Chowdhury A.K.A., Khan M.O.F., Hashim M.F. Antifertility activity of ether extract and a steroidal Component (HF) of the extract of the flowers of Hibiscus rosasinensis. Bangladesh Pharmaceutical Journal, 11(1), 16-19, 1993.
  12. Chowdhury A.K.A., Matin M.A., Islam M.A., Khan M.O.F, Prescribing pattern in acute diarrhoea in three districts in Bangladesh. Tropical Doctors, 23, 165-66, 1993.

 

Refereed Abstracts

  1. R.F. Borne and O.F. Khan, (a) Synthesis of Isoquinuclidine analogues as antimalarial agents, (b) Synthesis and Antimalarial Activity of Cyclen Analogues. Proceedings of the 3rd Annual Meeting of the Consortium for Antimalarial Development, September 5, 2003, New Orleans, Louisiana, USA.
  2. M.O.F. Khan, S.E. Austin, C. Chan, H. Kendrick, V. Yardley, S.L. Croft and K.T. Douglas Rational drug design of antitrypanosomal drug leads: Improved trypanothione reductase inhibitors. December, 2000. British Pharmaceutical Conference, Barmingham (UK). ‘Medicines - the future horizon’.
  3. M.O.F. Khan, C. Chan, H. Yin, S. E. Austin, S.L. Croft, P. Rock and K. T. Douglas. Rational design of second-generation improvements of tricyclic lead inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs. Eur. J. Pharm. Sci 6(Supp 1), S29, 1998.
  4. A.K.A. Chowdhury, O.F. Khan, M.A. Matin, K. Begum, M.A. Gulib, Effect of standard treatment guidelines with or without adult on prescribing for acute respiratory Infections in government health facilities in Bangladesh., Presented at the International Conference on Improving Use of Medicines: State of the Art and Future Directions, Chiang Mai, Thailand, April 1-4, 1997.
  5. Chowdhury A.K.A., Khan M.O.F, Matin M.A., Haque Z. Impact of standard treatment guidelines and small group training on prescribing for diarrhoea in under-five children in Bangladesh. INRUD News 5(2) 20 (1996). (International Network for Rational Use of Drugs’ News Letter)
  6. A.K.A. Chowdhury, O.F. Khan, M.A. Matin, A. Haque, A.L. Buiya. Effect of standard treatment guidelines with or without audit on prescribing for acute respiratory infections in government health facilities in Bangladesh. Report INRUD News Letter, 1995.

 

Patent (To be filed)

  1. M.O.F. Khan and R.F.Borne, et al, Synthesis and Antimalarial (in vitro and in vivo) and Antileishmanial Activity of Cyclen Analogs of Chloroquine. (To be filed).

 

SEMINARS/ SYMPOSIUM/ MEETING/ INVITED LECTURES

  1. April 24 – 26, 2006. AAPS Conference on Critical Issues in Discovering Quality Clinical Candidates, Hyatt Regency, Philadelphia, PA. M. Omar F. Khan, Kwan -K. Park, Henry J. Lee. Strategies of Structural Modifications for Safer Therapeutic agents: Antedrugs.
  2. April 24 – 26, 2006. IBC Life Science Drug Discovery and Development Summit, Tower Hall Funabori, Tokyo, Japan. Henry J. Lee, M. Omar F. Khan, Kwan -K. Park. A Novel Approach to potent, yet safer drugs: Antedrugs.
  3. March 26-30, 2006. 231st ACS National Meeting, Atlanta, GA. M. Omar F. Khan*, Kwan-K. Park and Henry J. Lee, Synthesis and biological evaluation of 21-thioalkylether derivatives of methyl 16-prednisolone carboxylates as a new class of anti-inflammatory steroidal antedrugs. (oral presentation).
  4. April 6-8, 2005. The 20th RCMI Annual Spring Simposium. Houston, Texas, International Houston Hotel. M.Omar F. Khan, Kwan K. Park, Henry J. Lee, Antedrugs: An Approach to Safer Drugs.
  5. February 24, 2005. Graduate Seminar Series. College of Pharmacy, Florida A & M University, Tallahassee, FL 32307. (Invited Lecture). Anti-trypanosomal and Anti-leishmanial Drug