Growth Hormone
Bovine Growth Hormone (BGH) acts to increase somatomedin secretion
in a manner similar to endogenous GH. The physiologic effects of
BGH is increased cellular glucose and amino acid uptake and lipolysis.
It is used in cattle to promote milk production. The dose is 500
mg every 2 weeks. Adverse effects include decreased food intake,
decreased rate of pregnancy, and uterine complications (complications with
gestation and delivery if conception does occur).
Gonadorelin (Gonadotropin Releasing Hormone, GnRH, Cystorelin®,
Factrel®)
Gonadorelin increases the synthesis and release of FSH and LH.
It is used in the treatment of follicular cysts and may also be used to
increase fertility in cows with previously retained placentæa.
Follicle Stimulating Hormone (FSH, F.S.H.-P®)
Stimulates follicular growth and œstrogen production in females and
spermatogenesis in males. It is used to induce œstrus for out-of-season
breeding and to increase the sperm count in breeding males.
Luteinising Hormone/Human Chorionic Gonadotropin is used in females to control ovulation and to treat persistent infertility. LH alone is used in male animals to increase testosterone production and cause testicular descent in cryptorchidism.
Œstrogens
Correction of anœstrus in cows (possibly effective) and horses.
Pyometra (inflammation with purulent exudate of the uterus) and mummified fœtus.
Problems associated with spaying (urinary incontinence, vaginitis, dermatitis).
Androgen dependent tumours.
To stimulate growth (anabolic effects -- limited efficacy).
Adverse effects of œstrogens include vaginal or rectal prolapse and abortion (their use is contraindicated during pregnancy).
Steroidal œstrogens most commonly used in veterinary practice include
œstrodiol (ECP®), œstrone, and œstriol.
Non-steroidal œstrogens
Progestins
Megœstrol (Ovaban®, Ovarid®) -- Used as a contraceptive in bitches and to alleviate false pregnancy. It is also used in the treatment of aggressive behaviour and unacceptable masculine behaviour in male dogs and in the treatment of urine-marking, aggression, and anxiety in cats.
Medroxyprogesterone (Provera®) -- Used in cats for the treatment of behavioural disorders and psychogenic alopecia/dermatitis and in dogs for the treatment of aggressive behaviours.
Androgens
Boldenone (Equipoise®, Vebonol®) -- used primarily in horses to promote growth in debilitated animals.
Mibolerone (Cheque® Drops) -- used to prevent heat (œstrus) in bitches. It should not be used in cats, due to a high incidence of hepatotoxicity and death.
Nandrolone (Durabolin®, Deca-Durabolin®) -- used primarily to stimulate erythropoiesis. It may also be used as an appetite stimulant in small animals.
Stanozolol (Winstrol®) -- used primarily for its anabolic effects. May also be used for the treatment of anæmias. Additionally, it may possess fibrinolytic activity and has been successful in the treatment of feline aortic thrombo-emboli.
Clorprostenol (Estrumate®) -- used to induce abortion, treatment of pyometra, and to induce œstrus in cows.
Fenprostelene (Bovilene®) -- used to induce abortion and induce œstrus in cows.
Fluprostenol (Equimate®) -- used to induce labour, abortion and
to induce œstrus in horses.